Molecular Imaging of Inflammation in Atherosclerosis Plaque Using Functionalized MRI Contrast Agent
نویسندگان
چکیده
H. ALSAID, G. De Souza, M. C. Bourdillon, F. Chaubet, A. Sulaiman, C. Zahir, E. Lancelot, D. Letourneur, A. Briguet, E. CanetSoulas Laboratoire de RMN UMR CNRS 5012. UCB Lyon1-ESCPE, Villeurbanne, France, EA 3740, Université UCB-Lyon1, Faculté Médecine Laennec, Lyon, France, INSERM U 698, Hôpital X. Bichat, Paris, France, CREATIS, UMR 5515 INSERM U 630, Radiologie, Hôpital Cardiologique, Bron, France, Guerbet, B.P. 50400, Roissy CdG cedex, France
منابع مشابه
Molecular MRI of Inflammation in Atherosclerosis
Inflammatory activity in atherosclerotic plaque is a risk factor for plaque rupture and atherothrombosis and may direct interventional therapy. Inflammatory activity can be evaluated at the (sub)cellular level using in vivo molecular MRI. This paper reviews recent progress in contrast-enhanced molecular MRI to visualize atherosclerotic plaque inflammation. Various MRI contrast agents, among oth...
متن کاملA New Theranostic System Based on Gd2O3 NPs coated Polycyclodextrin Functionalized Glucose for Molecular Magnetic Resonance Imaging (MMRI).
Introduction: Recent advances in nanoscience and biomedicine have attracted tremendous attention over the past decade to design and construct multifunctional nanoparticles that combine targeting, therapeutic, and diagnostic functions with a single platform to overcome the problems of conventional techniques for diagnosis and therapy with minimal toxicity. Materials ...
متن کاملSynthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...
متن کاملTargeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent
BACKGROUND The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothelium of blood vessels in response to pro-inflammatory stimuli is of major importance for the regulation of local inflammation in cardiovascular diseases such as atherosclerosis, myocardial infarction and stroke. In vivo molecular imaging of ICAM-1 will improve diagnosis and follow-up of patients by non-invas...
متن کاملSynthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...
متن کامل